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Beilstein J. Org. Chem. 2017, 13, 817–824, doi:10.3762/bjoc.13.82
Graphical Abstract
Figure 1: Representative bioactive imidazo[1,2-a]pyridine and isoquinoline-containing derivatives.
Scheme 1: GBB-based MCR strategy for the imidazo[1,2-a]pyridine-fused isoquinoline derivatives.
Beilstein J. Org. Chem. 2016, 12, 1487–1492, doi:10.3762/bjoc.12.145
Scheme 1: MCR to polycyclic fused imidazo[1,2-a]pyridine derivatives.
Figure 1: Syntheses of imidazo[1,2-a]pyridine derivatives. Reaction conditions: 2 (1.35 mmol), 3 (1 mmol), 4 ...
Figure 2: Mechanistic rationale for the MCR [36].
Beilstein J. Org. Chem. 2012, 8, 841–849, doi:10.3762/bjoc.8.94
Figure 1: Structures of Smo antagonists and agonists.
Scheme 1: General synthetic route for Sant-75. Reagents and conditions: (a) Pd(PPh3)4, PhMe, Na2CO3, H2O, 85 ...
Scheme 2: Substituent-modifications on the motif A. Reagents and conditions: (a) CH2Cl2, Et3N; (b) CH2Cl2, TF...
Scheme 3: Substituent-modifications on the motif A. Reagents and conditions: (a) (i) FeCl3, Zn, H2O, DMF, 100...
Scheme 4: Core modification on the motif A. Reagents and conditions: (a) BOP, DIEA, DMF; (b) CH2Cl2, TFA.
Figure 2: Core modification on the motif B.
Scheme 5: Synthesis of key intermediate biaryl aldehydes. Reagents and conditions: (a) Pd(OAc)2, PPh3, 1,4-di...
Scheme 6: Chemical modifications on the motif C. Reagents and conditions: (a) Pd(OAc)2, PPh3, 1,4-dioxane, Na2...
Scheme 7: Chemical modifications on the motif D. Reagents and conditions: (a) R2COCl, CH2Cl2.